|
KMID : 0364019930260020075
|
|
Korean Journal of Thoracic and Cardiovascular Surgery
1993 Volume.26 No. 2 p.75 ~ p.79
|
|
|
Myocardial Preserving Effect of Fructose-1, 6-diphosphate in Isolated Rat Heart
|
|
이철주
조수신/류재온/김문환/김세환/이익호/박소라/서창국
|
|
|
Abstract
|
|
|
Myocardial protection against ischemic and reperfusion injuries is still in troublesome eventhough couples of the way of myocardial protection have been applied since 1970's. One of the possibility in myocardial protection is adding Fructose-1,
6-diphosphate(FDP) in cardioplegic solution. It is assumed that FDP can promote ATP production under anaerobic condition as well inhibiting the supressing effect of lactate on phosphofructokinase.
We compared the myocardial protecting effects of FDP in crystalloid cardioplegic solution(St. Thomas formula, 10℃, pH=74) and reperfusate using isolated rat hearts in modified Langendorf apparatus by the parameters of preischemic and post
reperafusing
heart rate, time to first beat, occurance of arrhythmia, time to stabilization, and the rate of left ventricular pressure developing. Group A(n=10), containing no FDP in cardioplegic and reperfusing solutions was control. Group B(n=5), containing
FDP in
cardioplegic solution, showed statistically significant superiority of postischemic left ventricular pressure development than the control group. Group C(n=5). Containing FDP in reperfusate, showed statistically significant myocardial depressing
effect
than the controls. Other parameters were unremarkable. The cause in uncertain, but it is assumed that the negative feedback inhibition of FDP in energy metabolism or unknown blocking effect of FDP on certain transmembrane ionic currents is
present.
In conclusion, 1) FDP in cardioplegic solution has beneficial effect on postischemic left ventricular preservation. 2) FDP is strong acid hen is hydrolyzed, so precise acid titration is necessary. 3) FDP in reperfusate has negative left
ventricular
preservation, otherwise the mechanism is still uncertain. (Korean J Thoracic Cardiovas Surg 1994; 27:75-9)
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|
|